Tag Archives: computer simulation

Computer Model May Lead to Improved Anti-HIV Drug Combination Therapies

In a step toward the possibility of replacing drug “cocktails” with a single pill a day, Johns Hopkins and Harvard researchers have developed what they are calling “the first accurate computer simulation to explain drug effects.” To create the simulation, AIDS experts combined data collected during thousands of tests of more than 20 anti-HIV drugs.

“With the help of our simulation, we can now tell with a fair degree of certainty what level of viral suppression is being achieved – how hard it is for the virus to grow and replicate – for a particular drug combination, at a specific dosage and drug concentration in the blood, even when a dose is missed.”

— Robert Siliciano, M.D., Ph.D, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator

The computer model has already helped to explain how and why some patients without evidence of drug resistance fail to see improvements using some treatment regimens. Researchers expect the study findings will help to rule out drug combinations that are unlikely to work and thereby make clinical trials and development of future combination therapies more efficient.

How is technology changing your life for the better?

Learn more at http://www.eurekalert.org/pub_releases/2012-09/jhm-ads083012.php

http://www.hopkinsmedicine.org/pharmacology_molecular_sciences/faculty/bios/siliciano.html

http://www.hhmi.org/research/investigators/siliciano_bio.html

http://www.nature.com/nm/index.html

© Tony Leininger and IT for Good 2012. See sidebar for full copyright notice.

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Computer Simulation, Other Methods Could Replace Animal Testing

According to People for the Ethical Treatment of Animals (PETA), the Food and Drug Administration’s “Draft Guidance for Industry: Modified Risk Tobacco Product Applications,” will lead to animal studies being conducted if approved as currently written.

The group has therefore called on the FDA to change its guidance. Instead, PETA recommends FDA call for the use of “only modern, effective non-animal testing methods.” These include computer simulation, tests that use human cells, and clinical studies conducted with human smokers.

Everyone knows that tobacco products are inherently hazardous, addictive, and deadly and that decades of animal tests did not predict the link between smoking and cancer. PETA is calling on the FDA to make it clear, once and for all, that no more animals should suffer and die in tests for new tobacco products, ‘less harmful’ or not.”

Kathy Guillermo, Vice President of Laboratory Investigations, PETA

The methods PETA recommends for avoiding animal testing are currently in use in Canada and are widely available. Several countries, including Belgium, Germany, and the U.K., have banned animal testing of tobacco products.

How is technology changing your life for the better?

Learn more at http://www.eurekalert.org/pub_releases/2012-06/pfte-ptf060512.php

© Tony Leininger and IT for Good 2012. See sidebar for full copyright notice.